The climate is changing, game is disappearing, and two peoples of the Ice Age compete for survival in a savage world. Keena, from a powerful band of Neanderthals, and Shinoni, daughter of a Cro-Magnon shaman, are torn from their families by Haken, a ruthless hunter. The girls dislike each other but soon discover they need one another to survive. Together they escape but are pursued by Haken across an Ice Age landscape rumbling with advancing glaciers and teeming with mighty predators.

As Shinoni and Keena work to overcome disaster at every turn, they are joined by Tewa, a powerful she-wolf who becomes their guardian and spirit guide. Can their growing friendship overcome cultural, racial, and even species differences? Will they ever be able to get back to their families? Only the spirits know.